As a component of the Grand Challenges Vector-based Control of Transmission Discovery Research (VCTR) program, the Foundation for the National Institutes of Health (FNIH) is seeking innovative discovery projects to identify new chemical leads to fuel the development pathway for insecticides to control the mosquito vectors of malaria. $6 million in funding is available for this new grant program to discover chemical agents with novel mechanisms of action to kill mosquitoes.
Letters of Inquiry will be accepted through June 25, 2010.
Current efforts aimed at the control of the mosquito vectors of malaria rely heavily on a limited number of related products for insecticide treated bednets, for indoor residual spraying and for chemical larvicides. These products act on a very limited number of mosquito targets and are subject to failure as a result of the selection and spread of insecticide resistance. Despite the importance of insecticides in controlling the devastating impact of malaria, no new products have been developed for public health use in malaria endemic countries in 30 years.
To address this situation, this program seeks to support projects that will discover new active ingredients with novel mechanisms of action as the basis for insecticide development. It is envisioned that chemical leads identified in these projects can be taken forward in collaboration with industrial partner.
To learn more about the Request for Proposals and the on line LOI application process go to http://www.grandchallenges.org/FNIHvector
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