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Sunday, August 25, 2013

Leukemia & Lymphoma Society Invites Letters of Intent for New Idea Award

This is a concept award for innovative approaches that can fundamentally change our understanding, diagnosis and/or treatment of one or more hematological malignancies.
The Leukemia & Lymphoma Society (LLS) is proud to announce our second year ofThe New Idea Award, a grant program designed to identify novel research strategies with high potential for high impact on the future of blood cancer treatment(s).  Specifically, this program supports academic researchers with innovative ideas for approaches that are substantially different from standard therapies and prognostic/diagnostic modalities, as well as ideas that may fundamentally change our understanding of blood cancer(s).  Successful awards will describe potentially paradigm-shifting ideas that take research in a substantially new direction, and thus preliminary data is not required.
The goal of this program is to advance novel concepts that may eventually lead to significant improvements in the clinical outcomes, including quality of life, of patients with hematological malignancies.  Grants will support initial exploration of untested but potentially transformative research ideas and treatment approaches.  In order to receive such an award, applicants must succinctly describe the innovative idea/approach and a method for testing it within the one year grant period. 
Upon completion of the one year period, awardees will be evaluated on the extent to which their concept has been substantiated by initial testing, and promising projects may be selected for extended funding.  The long-term goal of The New Idea Award is to improve outcomes for more patients with hematological malignancies, recognizing that in some cases fundamental biological knowledge must first be achieved.
Grants will be awarded in an amount of up to $100,000 for a one year grant period. 
Investigators in academic laboratories are eligible to apply.  Investigators must demonstrate that their research environment is equipped and suitable for the proposed study.  Collaboration between multiple investigators to strengthen the proposed work will be considered favorably, but is not a requirement.  Applicants need not be United States (U.S.) citizens nor be associated with a U.S.-based institution.  Applicants should hold a Ph.D., M.D., D.V.M. or equivalent degree.
It is anticipated that each funded project will be unique and represent a high-risk, potentially high-reward opportunity.  
Concept awards are designed to allow initial exploration of new ideas with the potential to open truly new avenues of investigation.  Concept awards are NOT intended to support the logical progression of already established research programs.  Proposals that are an obvious extension of established research programs will be administratively triaged.  As such, it is unlikely that a significant amount of preliminary data will exist to support the proposal; however, preliminary data can be included to support the scientific rationale.  This is particularly true if the preliminary data shows an unexpected result which then forms the basis of the proposal.
Research Strategy and Feasibility:  1) Does the scientific rationale logically support the proposed study and is it feasible?
2) Are the aims, experimental design, methods, and analyses well-developed and integrated?  
3) Does the PI acknowledge problems and pitfalls?  
4) Is it reasonable to expect meaningful results to support or reject the original hypothesis in a one year time frame?
Achieving a favorable review will require that the proposed project be a new idea, and describe how the novel approach/idea could ultimately lead to a significant paradigm change.
There is a competitive Letter of Intent and access to the full application will be by invitation only. The research project description in the full application should be no more than 3 pages in length. Applications will be accepted electronically via the LLS Research Application Portal powered by FLUXX via the following link:
Please do not log into FLUXX or create a new account until after the program open date (September 6, 2013).  If you have applied to LLS prior you may simply need to validate your username and password.  Once in the system, you will be able to view our open programs and select the "New Idea Award" to create a proposal.  If you have any questions please contact us by e-mail at researchprograms@lls.org as soon as possible as we cannot extend the deadline for submission.
Call for Proposals: September 6, 2013 @ 9:00 AM ET
Letter of Intent due:  November 1, 2013 @ 3:00 PM ET
Invitation to submit full application:  December 15, 2013
Full Application Deadline: January 15, 2014 @ 3:00 PM ET
Scientific Peer Review Committee: March/April 2014
Notification of Awards: June 30, 2014
Anticipated Funding Start Date: October 2014
The Letter of Intent will be reviewed by LLS Research Staff with consultation from independent experts.  LOIs will be judged based on compliance with guidelines, eligibility, and responsiveness to the RFA.  LOIs that do not meet the criteria for this Award will be administratively triaged at this time.
Invited applications will be reviewed by an extensive peer review process which includes a diverse group of external experts covering both the science and medical aspects of the review. 
Final funding recommendations are created by our independent Medical & Scientific Advisors and approved by our Mission Oversight Committee.

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